High Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery
نویسندگان
چکیده
منابع مشابه
High Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery
The discovery of new therapeutic options against Trypanosoma cruzi, the causative agent of Chagas disease, stands as a fundamental need. Currently, there are only two drugs available to treat this neglected disease, which represents a major public health problem in Latin America. Both available therapies, benznidazole and nifurtimox, have significant toxic side effects and their efficacy agains...
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Drug screening is a long and costly process confronted with low productivity and challenges in using animals, which limit the discovery of new drugs. To improve drug screening efficacy and minimize animal testing, recent efforts have been dedicated to developing cell-based high throughput screening (HTS) platforms that can provide more relevant in vivo biological information than biochemical as...
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1Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand 2Graduate School of Science and Engineering, Yamaguchi University, Yamaguchi 753-8511, Japan 3Department of Veterinary & Biomedical Sciences, College of Agriculture & Biological Sciences, South Dakota State University, Brookings, SD 57006, USA 4Center of Infectious Disease and Signaling Research, Nation...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2014
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0003259